Archived Seminar: Memory, Learning to Learn, and Control of Cognitive Representations
Pioneers in Biomedical Research Seminar presented by the Fralin Biomedical Research Institute at VTC
About this Seminar
Biological neural networks can represent information in the collective action potential discharge of neurons, and store that information amongst the synaptic connections between the neurons that both comprise the network and govern its function. The strength and organization of synaptic connections adjust during learning, but many cognitive neural systems are multifunctional, making it unclear how continuous activity alternates between the transient and discrete cognitive functions like encoding current information and recollecting past information, without changing the connections amongst the neurons. This lecture will first summarize our investigations of the molecular and biochemical mechanisms that change synaptic function to persistently store spatial memory in the rodent hippocampus. Dr. Fenton will then report on how entorhinal cortex-hippocampus circuit function changes during cognitive training that creates memory, as well as learning to learn in mice. He will then describe how the hippocampus system operates like a competitive winner-take-all network, that, based on the dominance of its current inputs, self organizes into either the encoding or recollection information processing modes. Dr. Fenton's research finds no evidence that distinct cells are dedicated to those two distinct functions, rather activation of the hippocampus information processing mode is controlled by a subset of dentate spike events within the network of learning-modified, entorhinal-hippocampus excitatory and inhibitory synapses.
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Neurobiology Research. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. Presented virtually via Zoom primarily for research and clinical audiences, the lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.
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Andre Fenton, Ph.D.
Professor, Center for Neural Science, College of Arts and Science, Neuroscience Institute, NYU Langone Health, New York University