Archived Seminar: Running on Dopamine: Metabolic Regulation of Reward Seeking
Pioneers in Biomedical Research Seminar presented by the Fralin Biomedical Research Institute at VTC
Archived Seminar: Running on Dopamine: Metabolic Regulation of Reward Seeking
Date: Nov. 20, 2020
Time: 11:00 a.m. - 12:00 p.m.
Seminar Abstract
Dopamine plays an important role in the regulation of goal-directed behavior. To ensure energy homeostasis, goal-directed behavior has to be tuned according to physiological needs of the organism. However, despite the wealth of preclinical evidence on the link between disturbed energy homeostasis and altered dopamine signaling, this correspondence is not well understood in humans. In the talk, I will provide an integrative perspective on goal-directed behavior that incorporates energetic demands. Crucially, the emerging evidence on vagal afferent signals in regulating allostasis via changes in monoaminergic signaling suggests that non-invasive electrical stimulation of the vagus nerve may provide a means to perturb homeostatic and motivational circuits in the human brain. Thus, by emulating vagal afferent signals concurrently to fMRI, we can better elucidate the role of interoceptive feedback in regulating goal-directed behavior. Ultimately, this mechanism might help us explain why metabolic and motivational symptoms often co-occur in mental and metabolic disorders.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Human Neuroscience Research. The Fralin Biomedical Research Institute Pioneers in Biomedical Research Program offers the expertise of a range of scientists who are exploring frontiers in biomedical research. These seminars are open to Virginia Tech and Carilion Clinic faculty, students, and staff.
You May Also Be Interested In...
-
Home ItemSeminar: Team Science in Clinical Research , home
Aug. 27 2025, at 1 p.m. | Karen Johnston, M.D., M.Sc., Harrison Distinguished Professor of Neurology, Associate Vice President for Clinical and Translational Research, Director, integrated Translational Health Research Institute of Virginia (iTHRIV), University of Virginia School of Medicine | Seminar
-
Home ItemInheriting Chromatin Domains in Mammals and the Mechanisms Involved , home
Sept. 5, 2025, 11:00 a.m. | Thelma Escobar, Ph.D., Assistant Professor, Department of Biochemistry, Institute for Stem Cell & Regenerative Medicine, University of Washington | Co-Sponsored by the Fralin Biomedical Research Institute and Cancer Research Center — D.C.
-
Home ItemFlow Induced Endothelial Planar Polarity for Signaling Regulation , home
Sept. 19, 2025, 11:00 a.m. | Julia Mack, Ph.D., Assistant Adjunct Professor, David Geffen School of Medicine, Division of Cardiology, University of California Los Angeles | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home ItemThe Bitter Truth: Alcohol Use and Its Effects on Chemosensory Function , home
Oct. 3, 2025, 11:00 a.m. | Paule Valery Joseph, Ph.D., Lasker Clinical Research Scholar, NIH Distinguished Scholar; Acting Chief, Section of Sensory Science and Metabolism Unit, Co-Director of the National Smell and Taste Center, National Institute on Deafness and Other Communication Disorders; National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health | Co-Sponsored by the Fralin Biomedical Research Institute Center for Health Behaviors Research and Addiction Recovery Research Center
-
Home ItemOrganization and Control of Hippocampal Networks , home
Oct. 17, 2025, 11:00 a.m. | Ivan Soltesz, Ph.D., James R. Doty Professor of Neurosurgery and Neurosciences, Stanford University | Co-Sponsored by the Fralin Biomedical Research Institute Center for Neurobiology Research

Nils Kroemer, Ph.D.
Junior Group Leader of Computational Psychiatry in the Department of Psychiatry and Psychotherapy at the University of Tübingen