Archived Seminar: Running on Dopamine: Metabolic Regulation of Reward Seeking
Pioneers in Biomedical Research Seminar presented by the Fralin Biomedical Research Institute at VTC
Archived Seminar: Running on Dopamine: Metabolic Regulation of Reward Seeking
Date: Nov. 20, 2020
Time: 11:00 a.m. - 12:00 p.m.
Seminar Abstract
Dopamine plays an important role in the regulation of goal-directed behavior. To ensure energy homeostasis, goal-directed behavior has to be tuned according to physiological needs of the organism. However, despite the wealth of preclinical evidence on the link between disturbed energy homeostasis and altered dopamine signaling, this correspondence is not well understood in humans. In the talk, I will provide an integrative perspective on goal-directed behavior that incorporates energetic demands. Crucially, the emerging evidence on vagal afferent signals in regulating allostasis via changes in monoaminergic signaling suggests that non-invasive electrical stimulation of the vagus nerve may provide a means to perturb homeostatic and motivational circuits in the human brain. Thus, by emulating vagal afferent signals concurrently to fMRI, we can better elucidate the role of interoceptive feedback in regulating goal-directed behavior. Ultimately, this mechanism might help us explain why metabolic and motivational symptoms often co-occur in mental and metabolic disorders.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Human Neuroscience Research. The Fralin Biomedical Research Institute Pioneers in Biomedical Research Program offers the expertise of a range of scientists who are exploring frontiers in biomedical research. These seminars are open to Virginia Tech and Carilion Clinic faculty, students, and staff.
You May Also Be Interested In...
-
Home ItemIn Person at CNRIC: Hyperactivation of an RNA Binding Protein by Cancer-associated Mutations , home
April 19, 11:00 a.m., Collaboratory, Children's National Research and Innovation Campus, Washington, D.C. | Daniel Dominguez, Ph.D., Assistant Professor, Pharmacology, UNC School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Center (DC)
-
Home ItemIn Person Seminar: Our Mass Spectrometry Screening Studies in the Mouse and Human Hearts in Health and Disease , home
April 26, 2024, 11 a.m. | Anthony Gramolini, Ph.D., Professor, Physiology and Translational Biology and Engineering, Ted Rogers Centre for Heart Research, University of Toronto | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home ItemIn Person Seminar: Regulation of Mitochondrial Parameters in Skeletal Muscle , home
May 3, 2024, 11:00 a.m. | Glenn Rowe, Ph.D., Associate Professor of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham | Co-Sponsored by the Fralin Biomedical Research Institute Center for Exercise Medicine Research
-
Home ItemPlanning the Future of Environmental Health Sciences , home
May 9, 2024, 5:30 p.m. (Reception at 5 p.m.) | Rick Woychik, Ph.D., Director, National Institute of Environmental Health Sciences, National Institutes of Health | Maury Strauss Distinguished Public Lecture
-
Home ItemIn Person Seminar: Flavors in Tobacco and Nicotine Products: Science-based Regulation , home
May 10, 2024, 11:00 a.m. | Suchitra Krishnan-Sarin, Ph.D., Albert E. Kent Professor of Psychiatry, Yale School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Health Behaviors Research and the Addiction Recovery Research Center
Nils Kroemer, Ph.D.
Junior Group Leader of Computational Psychiatry in the Department of Psychiatry and Psychotherapy at the University of Tübingen