In Person Seminar: Cytoskeletal Control of Local Protein Synthesis and Directed Cardiac Growth
Benjamin Prosser, Ph.D.
Associate Professor
Physiology
Associate Director, Pennsylvania Muscle Institute
Director, Center for Epilepsy and NeuroDevelopmental Disorders
Perelman School of Medicine
University of Pennsylvania
Pioneers in Biomedical Research Seminar: Cytoskeletal Control of Local Protein Synthesis and Directed Cardiac Growth
Date: Feb. 23, 2024
Time: 11 a.m. - 12 p.m.
Archived video
About this Seminar
In response to stress, adaptive or maladaptive remodeling of heart muscle cells (i.e. cardiomyocyte hypertrophy) helps dictate the resulting structure and performance of the heart. Dr. Prosser and his lab find that upon increased demand, the cardiomyocyte microtubule network orchestrates the subcellular transport and positioning of mRNAs and the translational machinery to control where and when new protein synthesis occurs. Microtubule-based transport thus represents a novel, tunable mechanism to control and bias “local translation” in striated muscle, enabling the directed growth of cardiomyocytes to regulate cardiac form and function.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Vascular and Heart Research. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.
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