Archived Seminar: Genetics of Invasive Glioblastoma Cells
Pioneers in Biomedical Research Seminar presented by the Fralin Biomedical Research Institute at VTC
Archived Seminar: The Genetics of Invasive Glioblastoma Cells
Date: Oct. 9, 2020
Time: 11:00 a.m. - 12:00 p.m.
Glioblastoma (GBM), the most common adult brain cancer, is among the most genetically heterogeneous, treatment resistant, and lethal of all human cancers. Despite the genetic heterogeneity, a unifying characteristic of GBM is aggressive cell invasion into the brain parenchyma, which prevents complete surgical removal, increases the risk profile of adjuvant therapies, and virtually assures tumor recurrence. Recurrent GBM tumors are generally less sensitive to therapy than the original tumor and in most cases are located in critical brain areas, preventing a second surgical resection. Most GBM molecular studies to date focus on primary, newly diagnosed tumors, and as a consequence our knowledge of recurrent GBM biology is limited. It is clear however, that primary and recurrent GBM are in some ways distinct diseases, with the latter tumors reflecting selective pressures exerted by the standard-of-care adjuvant treatment paradigm for primary GBM tumor treatment (radiation and temozolomide (TMZ). Paradoxically, even though the biology of recurrent GBM is not fully understood, most of the clinical trials testing new GBM therapeutic agents are in the setting of recurrence. Thus, additional studies focused on recurrent tumors are necessary in order to generate more molecular information on these tumors and to aid in the development of new therapies that target these aggressive cells. Accordingly, we have conducted comprehensive genomic and transcriptomic analyses of patient-matched primary and recurrent GBM patient tumor core specimens with the goal of identifying new therapeutic targets for recurrent disease. These initial studies have identified the important signaling node(s) in recurrent GBM and thus a potential vulnerability for targeted agents.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Cancer Research Group. The Fralin Biomedical Research Institute Pioneers in Biomedical Research Program offers the expertise of a range of scientists who are exploring frontiers in biomedical research. These seminars are open to Virginia Tech and Carilion Clinic faculty, students, and staff.
You May Also Be Interested In...
-
Home ItemSeminar: Deciphering the Diverse Roles of Astrocytes in Stroke-glioma Interaction , home
Jan. 23, at 10 a.m. | Qi Ye, Ph.D., Postdoctoral Fellow, Department of Pediatric Neurology, Baylor College of Medicine | Seminar
-
Home ItemNeural Circuits for Social Behaviors , home
Jan. 24, 2025, 11:00 a.m. | Marcelo de Oliveira Dietrich, M.D., Ph.D., Associate Professor, Department of Comparative Medicine and Neuroscience, Yale School of Medicine | Co-Sponsored by the Center for Neurobiology Research, Fralin Biomedical Research Institute
-
Home ItemBlood-Based Approaches to Counter Aging , home
Jan. 31, 2025, 11:00 a.m. | Saul Villeda, Ph.D., Associate Professor, Chair, Department of Biomedical Science, University of California, San Francisco | Co-Sponsored by the Center for Exercise Medicine Research, Fralin Biomedical Research Institute
-
Home ItemDisability Identity, Inclusivity & Representation in Research , home
Feb. 14, 2025, 11:00 a.m. | Anjali Forber-Pratt, Ph.D., Director of Research, American Association on Health and Disability | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home ItemHow Big Med Drives Rising Healthcare Costs and What to Do About It , home
Feb. 20, 2025, 5:30 p.m. (Reception at 5 p.m.) | Vivian Ho, Ph.D., James A. Baker III Institute Chair in Health Economics, Baker Institute for Public Policy, Rice University | Maury Strauss Distinguished Public Lecture
Nhan Tran, Ph.D.
Professor in the Department of Cancer Biology at Mayo Clinic