Archived Seminar: Genetics of Invasive Glioblastoma Cells
Pioneers in Biomedical Research Seminar presented by the Fralin Biomedical Research Institute at VTC
Glioblastoma (GBM), the most common adult brain cancer, is among the most genetically heterogeneous, treatment resistant, and lethal of all human cancers. Despite the genetic heterogeneity, a unifying characteristic of GBM is aggressive cell invasion into the brain parenchyma, which prevents complete surgical removal, increases the risk profile of adjuvant therapies, and virtually assures tumor recurrence. Recurrent GBM tumors are generally less sensitive to therapy than the original tumor and in most cases are located in critical brain areas, preventing a second surgical resection. Most GBM molecular studies to date focus on primary, newly diagnosed tumors, and as a consequence our knowledge of recurrent GBM biology is limited. It is clear however, that primary and recurrent GBM are in some ways distinct diseases, with the latter tumors reflecting selective pressures exerted by the standard-of-care adjuvant treatment paradigm for primary GBM tumor treatment (radiation and temozolomide (TMZ). Paradoxically, even though the biology of recurrent GBM is not fully understood, most of the clinical trials testing new GBM therapeutic agents are in the setting of recurrence. Thus, additional studies focused on recurrent tumors are necessary in order to generate more molecular information on these tumors and to aid in the development of new therapies that target these aggressive cells. Accordingly, we have conducted comprehensive genomic and transcriptomic analyses of patient-matched primary and recurrent GBM patient tumor core specimens with the goal of identifying new therapeutic targets for recurrent disease. These initial studies have identified the important signaling node(s) in recurrent GBM and thus a potential vulnerability for targeted agents.
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Cancer Research Group. The Fralin Biomedical Research Institute Pioneers in Biomedical Research Program offers the expertise of a range of scientists who are exploring frontiers in biomedical research. These seminars are open to Virginia Tech and Carilion Clinic faculty, students, and staff.
You May Also Be Interested In...
Home ItemVirtual Seminar: Central Pattern Generation and Central Pain Suppression Circuits , home
Oct. 22, 2021, 11:00 a.m. | Fan Wang, Ph.D. | Pioneers in Biomedical Research Seminar Series
Redirect ItemNature Glial Biology in Medicine Conference (Virtual: Oct 25 - 26, 2021) , redirect
Presented by Virginia Tech's Fralin Biomedical Research Institute at VTC, in collaboration with Nature Communications, Nature Neuroscience and Nature Reviews Neuroscience.
Home ItemIn Person Public Lecture: Travels Around the Urea Cycle , home
Nov. 4, 2021 5:30 p.m. | Mark L. Batshaw, M.D. | Maury Strauss Distinguished Public Lecture
Home ItemVirtual Seminar: Autism, Face Perception, and the Amygdala , home
Nov. 12, 2021, 11:00 a.m. | Ralph Adolphs, Ph.D. | Pioneers in Biomedical Research Seminar Series
Home ItemIn Person Medical Scholar Lecture: Characterizing the Uncharacterized: Models to Understand Unknown Genetic Variants Related to Ventricular Arrhythmia and Sudden Death , home
Nov. 12, 2021, 1:00 p.m. | Lee L. Eckhardt, M.D. | Timothy A. Johnson Medical Scholar Lecture Series
Nhan Tran, Ph.D.
Professor in the Department of Cancer Biology at Mayo Clinic