In Person Seminar: Brainstem Serotonin Neurons Selectively Gate Retinal Information Flow to Thalamus
Mark L. Andermann, Ph.D.
Professor
Department of Medicine
Harvard Medical School
Beth Israel Deaconess Medical Center
Pioneers in Biomedical Research Seminar: Brainstem Serotonin Neurons Selectively Gate Retinal Information Flow to Thalamus
Date: Jan. 20, 2023
Time: 11 a.m. - 12 p.m.
About this Seminar
In this talk, Dr. Andermann will describe his lab's recent studies testing the hypothesis that neuromodulators might efficiently determine which visual information streams reach the cortex, by selective gating of transmission at specific retinal ganglion cell (RGC) axons in the thalamus. The lab found that optogenetic stimulation of serotonergic axons in visual thalamus of awake mice suppressed calcium activity and glutamate release in RGC boutons. Two-photon calcium imaging revealed that serotonin axon stimulation suppressed RGC boutons preferring global changes in luminance more than those preferring local visual stimuli, while the converse was true for suppression induced by increases in arousal. Convergent evidence from brain slice electrophysiology, immunohistochemistry, single cell sequencing and retinal electrophysiology indicates that presynaptic 5-HT1B receptors are enriched in RGC boutons preferring global luminance changes. Together, these data suggest a mechanism by which brainstem serotonin axons differentially suppress specific streams of visual information before they reach thalamocortical neurons.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Neurobiology Research. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.
You May Also Be Interested In...
-
Home ItemSeminar: Integrated Bioelectronic Systems for Biomedical Research and Healthcare: Materials, Electronics, and Computing , home
Feb. 7, 2023, 12 p.m. | Wei Ouyang, Ph.D., Postdoctoral Fellow, Querrey Simpson Institute for Bioelectronics, Northwestern University | Seminar
-
Home ItemSeminar: Molecular Targets of Prenatal Alcohol Exposure During Early Brain Development , home
Feb. 8, 2023, 2 p.m. | Karen Boschen, Ph.D., Postdoctoral Research Associate, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine | Seminar
-
Home ItemIn Person Lecture: Developmental Cognitive Neuroscience in the Era of Big Data , home
Feb. 9, 2023, 5:30 p.m. (Reception at 5 p.m.) | Damien Fair, PA-C, Ph.D., Professor, Institute of Child Development, Department of Pediatrics, College of Education and Human Development, University of Minnesota Medical School | Maury Strauss Distinguished Public Lecture
-
Home ItemIn Person Seminar: Pathogenic Mechanisms and Novel Therapies for Immune Neoplasms , home
Feb. 10, 2023, 11 a.m. | Ari Melnick, M.D., Gebroe Family Professor of Hematology/Oncology, and Director, Sackler Center for Biomedical and Physical Sciences, Weill Medical College, Cornell University | Pioneers in Biomedical Research Seminar Series | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Group
-
Home ItemIn Person Seminar: Behavioral Economic Approaches for Measuring Substance Use Severity and Motivating Change , home
Feb. 17, 2023, 11:00 am. | James G. Murphy, Ph.D., Professor, Department of Psychology, University of Memphis | Pioneers in Biomedical Research Seminar Series | Co-Sponsored by the Fralin Biomedical Research Institute Addiction Recovery Research Center and Center for Health Behaviors Research
-
Home ItemIn Person Seminar: Functional MRI of Dynamic Physiological States , home
Feb. 24 2023, 11:00 a.m. | Catherine Chang, Ph.D., Assistant Professor, Department of Electrical Engineering and Computer Science, Vanderbilt University | Pioneers in Biomedical Research Seminar Series | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research