Archived Seminar: Running on Dopamine: Metabolic Regulation of Reward Seeking
Pioneers in Biomedical Research Seminar presented by the Fralin Biomedical Research Institute at VTC
Dopamine plays an important role in the regulation of goal-directed behavior. To ensure energy homeostasis, goal-directed behavior has to be tuned according to physiological needs of the organism. However, despite the wealth of preclinical evidence on the link between disturbed energy homeostasis and altered dopamine signaling, this correspondence is not well understood in humans. In the talk, I will provide an integrative perspective on goal-directed behavior that incorporates energetic demands. Crucially, the emerging evidence on vagal afferent signals in regulating allostasis via changes in monoaminergic signaling suggests that non-invasive electrical stimulation of the vagus nerve may provide a means to perturb homeostatic and motivational circuits in the human brain. Thus, by emulating vagal afferent signals concurrently to fMRI, we can better elucidate the role of interoceptive feedback in regulating goal-directed behavior. Ultimately, this mechanism might help us explain why metabolic and motivational symptoms often co-occur in mental and metabolic disorders.
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Human Neuroscience Research. The Fralin Biomedical Research Institute Pioneers in Biomedical Research Program offers the expertise of a range of scientists who are exploring frontiers in biomedical research. These seminars are open to Virginia Tech and Carilion Clinic faculty, students, and staff.
You May Also Be Interested In...
Home ItemIn Person Seminar: Sustaining Power: Building Energy Networks in Striated Muscles , home
Sept. 22, 2023, 11:00 a.m. | Brian Glancy, Ph.D., Senior Investigator, Muscle Energetics Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health | Pioneers in Biomedical Research Seminar Series | Co-Sponsored by the Fralin Biomedical Research Institute Center for Exercise Medicine Research
Home ItemMachine Learning and Human Thought - A Modern Frontier , home
Sept. 28, 2023, 5:30 p.m. (Reception at 5 p.m.) | Read Montague, Ph.D., Virginia Tech Carilion Vernon Mountcastle Research Professor and Director, Center for Human Neuroscience Research, Fralin Biomedical Research Institute; Professor, Department of Physics, Virginia Tech College of Science | Maury Strauss Distinguished Public Lecture
Home ItemIn Person Seminar: Mitochondrial Ion Stress in Neurodegeneration , home
Sept. 29, 2023, 11:00 a.m. | Xinnan Wang, M.D., Ph.D., Associate Professor, Neurosurgery, Stanford University School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Neurobiology Research
Home ItemIn Person Seminar: Precision Medicine in Cardiac Electrophysiology , home
Oct. 6, 2023, 11:00 a.m. | Jennifer Silva, M.D., Professor of Pediatrics and Pediatric Cardiology, Director of Pediatric Electrophysiology, Washington University School of Medicine in St. Louis; Jonathan Silva, Ph.D., Professor, Biomedical Engineering and Computer Science and Engineering, Washington University in St. Louis; and | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
Home ItemCloudy with a Chance of Science: The Intersection of Wicked Problems, Perception, Communication, and Risk , home
Oct. 19, 5:30 p.m. (Reception at 5 p.m.) | J. Marshall Shepherd, Ph.D., Georgia Athletic Association Distinguished Professor of Atmospheric Sciences and Geography, Director, UGA Atmospheric Sciences Program, University of Georgia, and Member, National Academy of Engineering, National Academy of Sciences, and American Academy of Arts and Sciences | Maury Strauss Distinguished Public Lecture
Nils Kroemer, Ph.D.
Junior Group Leader of Computational Psychiatry in the Department of Psychiatry and Psychotherapy at the University of Tübingen