Special Seminar: Gene Therapy Targeting Vascular Function in Cardiovascular Disease: Are We There Yet?
Steven Fisher, M.D.
Professor
Department of Cardiology and Physiology
University of Maryland - Baltimore
Staff Physician
Baltimore VA Medical Center
Special Seminar: Gene Therapy Targeting Vascular Function in Cardiovascular Disease: Are We There Yet?
Date: May 20, 2022
Time: 11:00 a.m. - 12:00 p.m.
About this Seminar
This past decade has witnessed a renaissance in gene therapies for a broad array of human diseases. Dr. Fisher's talk will focus on mRNA splice variants as targets for gene therapies that by shifting the expression of naturally occurring protein isoforms may have therapeutic benefit. The specific focus is the smooth muscle myosin phosphatase (MP) enzyme, the end effector of vasodilation and key end target of signaling pathways regulating vessel tone and thus blood flow and blood pressure. Our data supports a model in which a splice variant of the MP regulatory subunit Mypt1 sets vascular sensitivity to NO , ANP, and ROS vasodilator signaling. After reviewing this data, Dr. Fisher will present his recent experiments testing the alternative gene therapy approaches of Crispr/Cas9 gene editing and splice-blocking anti-sense oligonucleotides targeting Mypt1 E24. These are potential novel therapies for hypertension and its sequelae HFpEF, the #1 preventable cause of early mortality world-wide.
You May Also Be Interested In...
-
Home Item
The Bitter Truth: Alcohol Use and Its Effects on Chemosensory Function , homeOct. 3, 2025, 11:00 a.m. | Paule Valery Joseph, Ph.D., Lasker Clinical Research Scholar, NIH Distinguished Scholar; Acting Chief, Section of Sensory Science and Metabolism Unit, Co-Director of the National Smell and Taste Center, National Institute on Deafness and Other Communication Disorders; National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health | Co-Sponsored by the Fralin Biomedical Research Institute Center for Health Behaviors Research and Addiction Recovery Research Center
-
Home Item
Organization and Control of Hippocampal Networks , homeOct. 17, 2025, 11:00 a.m. | Ivan Soltesz, Ph.D., James R. Doty Professor of Neurosurgery and Neurosciences, Stanford University | Co-Sponsored by the Fralin Biomedical Research Institute Center for Neurobiology Research
-
Home Item
Maury Strauss Distinguished Public Lecture , homeOct. 30, 2025, 5:30 p.m. (Reception at 5 p.m.) | Jennifer Munson, Ph.D., Professor and Director, Cancer Research Center — Roanoke, Fralin Biomedical Research Institute; Professor, Department of Biomedical Engineering and Mechanics, Virginia Tech College of Engineering | Maury Strauss Distinguished Public Lecture
-
Home Item
Thinking the Right Thoughts , homeOct. 31, 2025, 11 a.m. | Nathaniel Daw, Ph.D., Professor, Computational and Theoretical Neuroscience, Department of Psychology, Princeton University | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home Item
Maury Strauss Distinguished Public Lecture , homeNov. 6, 2025, 5:30 p.m. (Reception at 5 p.m.) | Teresa Lambe, Ph.D., OBE, Calleva Head of Vaccine Immunology, Professor of Vaccinology and Immunology, University of Oxford | Maury Strauss Distinguished Public Lecture
-
Home Item
Understanding Vascular Morphogenesis and Morphology: Live Insights from Zebrafish , homeNov. 21, 2025, 11:00 a.m. | Arndt F. Siekmann, Ph.D., Associate Professor, Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania | Co-Sponsored by the Center for Vascular and Heart Research, Fralin Biomedical Research Institute