Virtual Seminar: Dissecting Toxicities of Immune Checkpoint Inhibitors
Douglas Johnson, M.D., MSCI
Associate Professor of Medicine
Clinical Director, Melanoma Program
Ingram Cancer Center
Vanderbilt University
Virtual Pioneers in Biomedical Research Seminar: Dissecting Toxicities of Immune Checkpoint Inhibitors
Nov. 19, 2021
11:00 a.m. to 12:00 p.m.
Archived video
About this Seminar
Anti-PD-1 therapy has dramatically altered cancer treatments, but many unanswered questions remain. First, the need for more accurate biomarkers to provide clues to the pathogenesis of response and resistance, and to more accurately assign patients to effective treatment remains a key unmet need. Tumor cell expression of MHC class II and tumor mutational burden are two potential markers of response. Second, patients treated with anti-PD-1, especially when used in combination, frequently experience severe immune-related toxicities. Identifying patients at risk, clinically phenotyping clinical events, and determine effective treatment strategies remain unmet needs. In this presentation, Dr. Johnson will discuss his lab's work in identifying anti-PD-1 biomarkers, particularly focusing on MHC-II and tumor mutational burden, and in characterizing anti-PD-1 toxicities.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Cancer Research Group. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.
You May Also Be Interested In...
-
Home ItemTransformation of Information from the External World by Cortical Circuits During Learning , home
May 9, 2025, 11:00 a.m. | Alison Barth, Ph.D., Professor, Department of Biological Sciences, Carnegie Mellon University | Co-Sponsored by the Center for Neurobiology Research, Fralin Biomedical Research Institute
-
Home ItemThe Role of Exercise in Memory Function , home
May 23, 2025, 11:00 a.m. | Henriette van Praag, Ph.D., Associate Professor, Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University | Co-Sponsored by the Center for Exercise Medicine Research, Fralin Biomedical Research Institute
-
Home ItemPathways and Regulation of Cardiac Nav1.5 Channel Trafficking in Adult Myocytes , home
May 30, 2025, 11:00 a.m. | Gea-Ny Tseng, Ph.D., Professor, Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home ItemTargeting Acquired Dependencies During Tumor Evolution , home
June 6, 2025, 11:00 a.m. | Kris Wood, Ph.D., Associate Professor, Department of Pharmacology and Cancer Biology, Duke University School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Center – D.C.