Virtual Seminar: Tumor Intrinsic and Extrinsic Mechanisms Promoting Brain Metastasis
Diana Cittelly, Ph.D.
Associate Professor of Pathology
University of Colorado Anschutz Medical Campus
Virtual Pioneers in Biomedical Research Seminar: Tumor Intrinsic and Extrinsic Mechanisms Promoting Brain Metastasis
Jan. 28, 2022
11:00 a.m. to 12:00 p.m.
About this Seminar
Brain metastases have emerged as an unmet clinical need in cancer research. Recent advances show that cancer cells adapt to unique features and cells within the brain microenvironment, and that paracrine mechanisms initiated in the brain niche are critical for metastatic colonization and outgrowth. With a focus on breast-to-brain metastasis, this seminar will show how estradiol acts on estrogen-receptor positive (ER+) astrocytes leading to the upregulation of growth factors and chemokines than in a paracrine manner, promote brain metastatic traits in breast cancer cells lacking ERs (or triple-negative breast cancer). This seminar will explore a novel function of ovarian and brain-derived estrogens in the modulation of neuroinflammatory responses during brain metastatic progression.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Cancer Research Group. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.
You May Also Be Interested In...
-
Home Item
Transformation of Information from the External World by Cortical Circuits During Learning , homeMay 9, 2025, 11:00 a.m. | Alison Barth, Ph.D., Professor, Department of Biological Sciences, Carnegie Mellon University | Co-Sponsored by the Center for Neurobiology Research, Fralin Biomedical Research Institute
-
Home Item
The Role of Exercise in Memory Function , homeMay 23, 2025, 11:00 a.m. | Henriette van Praag, Ph.D., Associate Professor, Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University | Co-Sponsored by the Center for Exercise Medicine Research, Fralin Biomedical Research Institute
-
Home Item
Pathways and Regulation of Cardiac Nav1.5 Channel Trafficking in Adult Myocytes , homeMay 30, 2025, 11:00 a.m. | Gea-Ny Tseng, Ph.D., Professor, Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home Item
Targeting Acquired Dependencies During Tumor Evolution , homeJune 6, 2025, 11:00 a.m. | Kris Wood, Ph.D., Associate Professor, Department of Pharmacology and Cancer Biology, Duke University School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Center – D.C.