Virtual Seminar: Tumor Intrinsic and Extrinsic Mechanisms Promoting Brain Metastasis
Diana Cittelly, Ph.D.
Associate Professor of Pathology
University of Colorado Anschutz Medical Campus
Virtual Pioneers in Biomedical Research Seminar: Tumor Intrinsic and Extrinsic Mechanisms Promoting Brain Metastasis
Jan. 28, 2022
11:00 a.m. to 12:00 p.m.
About this Seminar
Brain metastases have emerged as an unmet clinical need in cancer research. Recent advances show that cancer cells adapt to unique features and cells within the brain microenvironment, and that paracrine mechanisms initiated in the brain niche are critical for metastatic colonization and outgrowth. With a focus on breast-to-brain metastasis, this seminar will show how estradiol acts on estrogen-receptor positive (ER+) astrocytes leading to the upregulation of growth factors and chemokines than in a paracrine manner, promote brain metastatic traits in breast cancer cells lacking ERs (or triple-negative breast cancer). This seminar will explore a novel function of ovarian and brain-derived estrogens in the modulation of neuroinflammatory responses during brain metastatic progression.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Cancer Research Group. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.
You May Also Be Interested In...
-
Home Item
Clinical Applications of Cancer Genetics , homeNov. 21, 2024, 5:30 p.m. (Reception at 5 p.m.) | Luis Diaz, Jr., M.D., Head, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center; Member, National Academy of Medicine | Maury Strauss Distinguished Public Lecture
-
Home Item
A Ribocentric View of Muscle Proteostasis in Health and Disease: Novel Mechanisms Potential Therapeutic Opportunities , homeNov. 22, 2024, 11:00 a.m. | Gustavo A. Nader, Ph.D., FAPS, Professor, College of Health and Human Development; Chair, Molecular, Cellular, and Integrative Physiology; Huck Institutes of the Life Sciences; The Pennsylvania State University | Co-Sponsored by the Fralin Biomedical Research Institute Center for Exercise Medicine Research
-
Home Item
Human Laboratory Evaluation of Cannabis Products , homeDec. 13, 2024, 11:00 a.m. | Ryan Vandrey, Ph.D., Professor, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Health Behaviors Research and the Addiction Recovery Research Center
-
Home Item
Mechanics of Convective Cell Motion , homeJan. 10, 2025, 11:00 a.m. | Michael Murrell, Ph.D., Associate Professor, Department of Biomedical Engineering and Physics, Yale University | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Center – Roanoke
-
Home Item
The Role of Pericytes in Pulmonary Vascular Diseases , homeJan. 17, 2025, 11:00 a.m. | Vinicio de Jesus Perez, M.D., FCCP, FAHA, Assistant Professor, Wall Center Adult PH Clinic Division of Pulmonary and Critical Care Medicine, Stanford School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home Item
Rethinking Human Health with AI: Solving Old Mysteries with Modern Tools , homeJan. 23, 2025, 5:30 p.m. (Reception at 5 p.m.) | Regina Barzilay, Ph.D., School of Engineering Distinguished Professor for AI and Health; AI Faculty Lead, Jameel Clinic; MIT Computer Science & Artificial Intelligence Lab; MacArthur Fellow; Member, National Academy of Engineering, American Academy of Arts and Sciences, and the National Academy of Medicine | Maury Strauss Distinguished Public Lecture