In Person Seminar: An Epigenome Atlas of the Embryonic Mouse Brain to Study Interneuron Neurogenesis in Normal Development and Disease Models
Timothy Petros, Ph.D.
Investigator
Unit on Cellular and Molecular Neurodevelopment
Eunice Kennedy Shriver National Institute of Child Health & Human Development
National Institutes of Health
Pioneers in Biomedical Research Seminar: An Epigenome Atlas of the Embryonic Mouse Brain to Study Interneuron Neurogenesis in Normal Development and Disease Models
Date: Dec. 15, 2023
Time: 11 a.m. - 12 p.m.
About this Seminar
A comprehensive characterization of epigenomic organization in the embryonic mouse forebrain will enhance our understanding of neurodevelopment and provide insight into mechanisms of neurological disease. This is particularly relevant for GABAergic inhibitory interneurons, an extremely heterogenous population of cells that is critical for nearly all aspects of brain function. Dr. Petros and his research team recently generated an ‘Epigenome Atlas’ characterizing the transcriptome, chromatin accessibility, histone modifications and higher order chromatin structure in four different embryonic brain regions that give rise to distinct neuronal subtypes. After establishing this ground truth, the lab is now investigating how perturbations in epigenetic regulation affect fate, maturation and function of inhibitory interneurons.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Neurobiology Research. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.
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