Archived Seminar: Neurovascular Interactions: Mechanisms, Imaging, Therapeutics
Pioneers in Biomedical Research Seminar presented by the Fralin Biomedical Research Institute at VTC
Neurovascular Interactions: Mechanisms, Imaging, Therapeutics
Date: Oct. 30, 2020
Time: 11:00 a.m. - 12:00 p.m.
Virtual Access: Virginia Tech and Carilion Clinic faculty, staff, and students will be sent an email with Zoom login credentials. Participants may also watch the lecture via YouTube livestream on our Live Webcast page.
About This Seminar
The communication between the brain, immune and vascular systems is a key contributor to the onset and progression of neurological diseases. Dr. Akassoglou’s research has uncovered the blood clotting factor fibrinogen as a driver of neuroinflammation, as common thread in a wide range of neurologic diseases, such as multiple sclerosis, Alzheimer’s disease and neurodegenerative diseases. Her lab developed cutting-edge imaging tools to study the neurovascular interface and discovered a role for fibrin in microglia-mediated oxidative stress-dependent spine elimination and novel fibrin-targeting immunotherapy to protect the brain from pathogenic neuroinflammation. Recent advances in functional single-cell transcriptional profiling of neurotoxic innate immunity (Tox-Seq) allowed the development of the oxidative stress cell atlas at the neurovascular interface. These findings could be a common thread for the understanding of the etiology, mechanisms of progression, and the development of new treatments for neurologic diseases with neuroimmune and cerebrovascular dysfunction.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Neurobiology Research and the Center for Glial Biology in Health, Disease, and Cancer. The Fralin Biomedical Research Institute Pioneers in Biomedical Research Program offers the expertise of a range of scientists who are exploring frontiers in biomedical research. These seminars are open to Virginia Tech and Carilion Clinic faculty, students, and staff.
You May Also Be Interested In...
-
Home ItemIn Person at CNRIC: Hyperactivation of an RNA Binding Protein by Cancer-associated Mutations , home
April 19, 11:00 a.m., Collaboratory, Children's National Research and Innovation Campus, Washington, D.C. | Daniel Dominguez, Ph.D., Assistant Professor, Pharmacology, UNC School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Center (DC)
-
Home ItemIn Person Seminar: Our Mass Spectrometry Screening Studies in the Mouse and Human Hearts in Health and Disease , home
April 26, 2024, 11 a.m. | Anthony Gramolini, Ph.D., Professor, Physiology and Translational Biology and Engineering, Ted Rogers Centre for Heart Research, University of Toronto | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home ItemIn Person Seminar: Regulation of Mitochondrial Parameters in Skeletal Muscle , home
May 3, 2024, 11:00 a.m. | Glenn Rowe, Ph.D., Associate Professor of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham | Co-Sponsored by the Fralin Biomedical Research Institute Center for Exercise Medicine Research
-
Home ItemPlanning the Future of Environmental Health Sciences , home
May 9, 2024, 5:30 p.m. (Reception at 5 p.m.) | Rick Woychik, Ph.D., Director, National Institute of Environmental Health Sciences, National Institutes of Health | Maury Strauss Distinguished Public Lecture
-
Home ItemIn Person Seminar: Flavors in Tobacco and Nicotine Products: Science-based Regulation , home
May 10, 2024, 11:00 a.m. | Suchitra Krishnan-Sarin, Ph.D., Albert E. Kent Professor of Psychiatry, Yale School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Health Behaviors Research and the Addiction Recovery Research Center
Katerina Akassoglou, Ph.D.
Senior Investigator at the Gladstone Institutes; and a Professor in the Department of Neurology at the University of California San Francisco