In Person Seminar: Brainstem Serotonin Neurons Selectively Gate Retinal Information Flow to Thalamus
Mark L. Andermann, Ph.D.
Department of Medicine
Harvard Medical School
Beth Israel Deaconess Medical Center
Pioneers in Biomedical Research Seminar: Brainstem Serotonin Neurons Selectively Gate Retinal Information Flow to Thalamus
About this Seminar
In this talk, Dr. Andermann will describe his lab's recent studies testing the hypothesis that neuromodulators might efficiently determine which visual information streams reach the cortex, by selective gating of transmission at specific retinal ganglion cell (RGC) axons in the thalamus. The lab found that optogenetic stimulation of serotonergic axons in visual thalamus of awake mice suppressed calcium activity and glutamate release in RGC boutons. Two-photon calcium imaging revealed that serotonin axon stimulation suppressed RGC boutons preferring global changes in luminance more than those preferring local visual stimuli, while the converse was true for suppression induced by increases in arousal. Convergent evidence from brain slice electrophysiology, immunohistochemistry, single cell sequencing and retinal electrophysiology indicates that presynaptic 5-HT1B receptors are enriched in RGC boutons preferring global luminance changes. Together, these data suggest a mechanism by which brainstem serotonin axons differentially suppress specific streams of visual information before they reach thalamocortical neurons.
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Neurobiology Research. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.
You May Also Be Interested In...
Home ItemIn Person Seminar: Win to Fight and Lose to Flight: Innate Yet Flexible Aggression Circuit , home
March 24, 2023, 11 a.m. | Dayu Lin, Ph.D., Professor, Department of Psychiatry, Grossman School of Medicine, New York University | Pioneers in Biomedical Research Seminar Series | Co-Sponsored by the Fralin Biomedical Research Institute Center for Neurobiology Research
Home ItemSeminar: Signaling and Metabolic Control of Nucleotide Metabolism in Cancer , home
March 27, 2023, 11 a.m. | Eunus S. Ali, Ph.D., Postdoctoral Associate, Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University | Seminar
Home ItemIn Person Seminar: Quantifying Diverse Research Representation , home
March 31, 2023, 11:00 a.m. | Jonathan Jackson, Ph.D., Executive Director, Community Access, Recruitment, and Engagement (CARE) Research Center, Harvard University and Massachusetts General Hospital | Pioneers in Biomedical Research Seminar Series | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
Home ItemIn Person Lecture: Synaptic Injury: A Link to the Past , home
March 31, 2023, 1 p.m. | Terrance Kummer, M.D., Ph.D., Associate Professor of Neurology, Washington University School of Medicine in St. Louis | Timothy A. Johnson Medical Scholar Lecture Series
Home ItemSeminar: Understanding Cancer: From Development to Therapy , home
April 5, 2023, 11 a.m. | Biplab Dasgupta, M.S., Ph.D., MBA, Professor of Pediatrics, Division of Oncology, Cincinnati Children's Hospital | Seminar
Home ItemIn Person Seminar: Brain Dynamics and Flexible Behaviors , home
April 14, 2023, 11:00 am. | Lucina Q. Uddin, Ph.D., Professor in Residence, Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles | Pioneers in Biomedical Research Seminar Series | Co-Sponsored by the Fralin Biomedical Research Institute Addiction Recovery Research Center and Center for Health Behaviors Research