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In Person Seminar: Prioritizing Individuals and Individual Differences in the Study of Children with Neurodevelopmental Disorders

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Bradley Schlaggar, M.D., Ph.D.

President and Chief Executive Officer,
Zanvyl Krieger Faculty Endowed Chair
Kennedy Krieger Institute
Department of Neurology and Department of Pediatrics
Johns Hopkins University School of Medicine

Pioneers in Biomedical Research Seminar: Prioritizing Individuals and Individual Differences in the Study of Children with Neurodevelopmental Disorders

Date: Jan. 27, 2023

Time: 11 a.m. - 12 p.m.

About this Seminar

The human central nervous system constitutes, arguably, the most complex biological system known.  The myriad and heterogeneous clinical manifestations of disorders of the developing nervous system, both rare and common, reflect that complexity. Commonly, the study of typical and atypical neurodevelopment embraces central tendency assumptions and approaches to investigation.  However, if we are to move effectively towards a precision medicine for neurodevelopmental disorders, we will need to shift our approach to methodologies that afford us an individual-level analysis. Dr. Schlaggar's talk, organized into two sections, will first assess the utility of functional MRI to investigate the development and plasticity of brain systems at the group- and individual-level of analysis. The discussion will then evaluate the reliance on central tendency-based approaches to investigating the etiology and treatment of developmental brain dysfunction and make the case for attending to heterogeneity in study design and clinical care.

Additional Details

This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Human Neuroscience Research. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.

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