Virginia Tech® home

A Novel Bispecific Antibody to Target the Brain Tumor Microenvironment

Insert your title here

Your Text Here
Kyuson Yun, Ph.D.

Kyuson Yun, Ph.D.

Associate Professor
Department of Neurology
Houston Methodist Chair, Neurodegenerative Disease Research
Houston Methodist Research Institute
Weill Cornell Medical College
View Speaker Profile
Pioneers in Biomedical Research Seminar

A Novel Bispecific Antibody to Target the Brain Tumor Microenvironment

Date: May 2, 2025

Time: 11 a.m. - 12 p.m.

In-person: Room G101 A/B, 4 Riverside Circle, Roanoke, Virginia

Virtual: Watch via Zoom

Watch via Zoom

About this Seminar

While immunotherapies have shown remarkable efficacy in some cancers, most solid tumors, including brain cancers, are resistant to immunotherapies. Immunotherapies are ideal for treating brain cancers since immune cells can cross the blood brain barrier (BBB) and track and selectively kill infiltrating brain cancer cells while sparing normal brain cells.  Unfortunately, most brain cancer trials with immunotherapies have failed to demonstrate significant benefits to brain cancer patients thus far. Dr. Yun and her team recently identified S100A4 as a critical regulator of immune suppressive myeloid and T cells in GBM through single cell sequencing analysis, and developed a novel S100A4 blocking antibody. To enhance BBB penetration, we also developed a bispecific antibody that crosses the BBB and reprograms the GBM TME to more an inflammatory state.  Dr. Yun will discuss our progress in understanding the immune suppressive microenvironment in GBM and the therapeutic potential of a novel bispecific antibody for treating brain cancers.

Additional Details

This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Cancer Research Center — Roanoke. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.

You May Also Be Interested In...

  • Home Item
    Clinical Applications of Cancer Genetics
    Clinical Applications of Cancer Genetics , home

    Nov. 21, 2024, 5:30 p.m. (Reception at 5 p.m.) | Luis Diaz, Jr., M.D., Head, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center; Member, National Academy of Medicine | Maury Strauss Distinguished Public Lecture

  • Home Item
    A Ribocentric View of Muscle Proteostasis in Health and Disease: Novel Mechanisms Potential Therapeutic Opportunities
    A Ribocentric View of Muscle Proteostasis in Health and Disease: Novel Mechanisms Potential Therapeutic Opportunities , home

    Nov. 22, 2024, 11:00 a.m. | Gustavo A. Nader, Ph.D., FAPS, Professor, College of Health and Human Development; Chair, Molecular, Cellular, and Integrative Physiology; Huck Institutes of the Life Sciences; The Pennsylvania State University | Co-Sponsored by the Fralin Biomedical Research Institute Center for Exercise Medicine Research

  • Home Item
    Human Laboratory Evaluation of Cannabis Products
    Human Laboratory Evaluation of Cannabis Products , home

    Dec. 13, 2024, 11:00 a.m. | Ryan Vandrey, Ph.D., Professor, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Health Behaviors Research and the Addiction Recovery Research Center

  • Home Item
    Mechanics of Convective Cell Motion
    Mechanics of Convective Cell Motion , home

    Jan. 10, 2025, 11:00 a.m. | Michael Murrell, Ph.D., Associate Professor, Department of Biomedical Engineering and Physics, Yale University | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Center – Roanoke

  • Home Item
    The Role of Pericytes in Pulmonary Vascular Diseases
    The Role of Pericytes in Pulmonary Vascular Diseases , home

    Jan. 17, 2025, 11:00 a.m. | Vinicio de Jesus Perez, M.D., FCCP, FAHA, Assistant Professor, Wall Center Adult PH Clinic Division of Pulmonary and Critical Care Medicine, Stanford School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research

  • Home Item
    Rethinking Human Health with AI: Solving Old Mysteries with Modern Tools
    Rethinking Human Health with AI: Solving Old Mysteries with Modern Tools , home

    Jan. 23, 2025, 5:30 p.m. (Reception at 5 p.m.) | Regina Barzilay, Ph.D., School of Engineering Distinguished Professor for AI and Health; AI Faculty Lead, Jameel Clinic; MIT Computer Science & Artificial Intelligence Lab; MacArthur Fellow; Member, National Academy of Engineering, American Academy of Arts and Sciences, and the National Academy of Medicine | Maury Strauss Distinguished Public Lecture