The Role of Exercise in Memory Function

About this Seminar

Evidence from human and animal studies that exercise benefits brain function, and may delay or prevent the onset of neurodegenerative conditions. In particular, the hippocampus, a brain area essential for learning and memory, is modulated by exercise training. In rodents, new neuron number in the dentate gyrus of the hippocampus is substantially increased by voluntary wheel running. Enhanced adult hippocampal neurogenesis is associated with changes in synaptic plasticity, neurotrophins, neuronal connectivity, learning and memory. Recent research indicates that factors secreted from peripheral organs convey running-induced changes in the brain. We identified lysosomal enzyme Cathepsin B as a novel myokine that influences memory function. Dr. Van Praag's research aims to understand the cellular mechanisms underlying muscle-brain interactions and to further our understanding of effects of exercise on the brain.

Additional Details

This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Exercise Medicine Research. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.

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