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Archived Seminar: Development of Genome Editor Therapies for Angelman Syndrome

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Mark Zylka, Ph.D. headshot

Mark J. Zylka, Ph.D.

W.R. Kenan, Jr. Distinguished Professor
Director, UNC Neuroscience Center
University of North Carolina at Chapel Hill
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Pioneers in Biomedical Research Seminar

Development of Genome Editor Therapies for Angelman Syndrome

Date: Sept. 13, 2024

Time: 11 a.m. - 12 p.m.

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About this Seminar

Angelman syndrome is a debilitating neurodevelopmental disorder caused by deletion of the maternal copy of Ube3a. Dr. Zylka's lab has been developing a variety of genome editor based treatments that restore the functional but epigenetically silenced copy of paternal Ube3a. Editors include CRISPR/Cas9 (active and catalytically dead) and zinc finger nucleases.

Additional Details

This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Neurobiology Research. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.

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