Virginia Tech® home

A Ribocentric View of Muscle Proteostasis in Health and Disease: Novel Mechanisms Potential Therapeutic Opportunities

Insert your title here

Your Text Here
Gustavo Nader, Ph.D., FAPS headshot

Gustavo Nader, Ph.D., FAPS

Professor
College of Health and Human Development
Chair, Molecular, Cellular, and Integrative Physiology
Huck Institutes of the Life Sciences
The Pennsylvania State University
View Speaker Profile
Pioneers in Biomedical Research Seminar

A Ribocentric View of Muscle Proteostasis in Health and Disease: Novel Mechanisms Potential Therapeutic Opportunities

Date: Nov. 22, 2024

Time: 11 a.m. - 12 p.m.

Download Flyer

About this Seminar

Loss of skeletal muscle mass is associated with functional impairments, disability and increased mortality. Treatments to prevent muscle loss are an urgent unmet clinical need.  Therefore, understanding the mechanisms that regulate muscle mass will provide potential clinical targets to improve quality of life and survival of aged individuals, and those suffering from a wide variety of chronic disorders. In this seminar, Dr. Nader will present mechanistic evidence demonstrating that muscle anabolism is determined by the ability of the muscle to synthesize ribosomes. He will focus the discussion on the regulation of ribosomal DNA transcription by RNA Polymerase I and will provide evidence for a role of the mechanistic target of Rapamycin (mTOR) in both transcriptional and epigenetic regulation of rDNA genes. Dr. Nader will also discuss how alterations in proteostasis negatively impact rDNA transcription and muscle mass.

Additional Details

This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Exercise Medicine Research. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.

You May Also Be Interested In...

  • Home Item
    Inheriting Chromatin Domains in Mammals and the Mechanisms Involved
    Inheriting Chromatin Domains in Mammals and the Mechanisms Involved , home

    Sept. 5, 2025, 11:00 a.m. | Thelma Escobar, Ph.D., Assistant Professor, Department of Biochemistry, Institute for Stem Cell & Regenerative Medicine, University of Washington | Co-Sponsored by the Fralin Biomedical Research Institute and Cancer Research Center — D.C.

  • Home Item
    Flow Induced Endothelial Planar Polarity for Signaling Regulation
    Flow Induced Endothelial Planar Polarity for Signaling Regulation , home

    Sept. 19, 2025, 11:00 a.m. | Julia Mack, Ph.D., Assistant Adjunct Professor, David Geffen School of Medicine, Division of Cardiology, University of California Los Angeles | Co-Sponsored by the Center for Vascular and Heart Research, Fralin Biomedical Research Institute

  • Home Item
    The Bitter Truth: Alcohol Use and Its Effects on Chemosensory Function
    The Bitter Truth: Alcohol Use and Its Effects on Chemosensory Function , home

    Oct. 3, 2025, 11:00 a.m. | Paule Valery Joseph, Ph.D., Lasker Clinical Research Scholar, NIH Distinguished Scholar; Acting Chief, Section of Sensory Science and Metabolism Unit, Co-Director of the National Smell and Taste Center, National Institute on Deafness and Other Communication Disorders; National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health | Co-Sponsored by the Fralin Biomedical Research Institute Center for Health Behaviors Research and Addiction Recovery Research Center

  • Home Item
    Organization and Control of Hippocampal Networks
    Organization and Control of Hippocampal Networks , home

    Oct. 17, 2025, 11:00 a.m. | Ivan Soltesz, Ph.D., James R. Doty Professor of Neurosurgery and Neurosciences, Stanford University | Co-Sponsored by the Fralin Biomedical Research Institute Center for Neurobiology Research

  • Home Item
    Thinking the Right Thoughts
    Thinking the Right Thoughts , home

    Oct. 31, 2025, 11 a.m. | Nathaniel Daw, Ph.D., Professor, Computational and Theoretical Neuroscience, Department of Psychology, Princeton University | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research

  • Home Item
    Understanding Vascular Morphogenesis and Morphology: Live Insights from Zebrafish
    Understanding Vascular Morphogenesis and Morphology: Live Insights from Zebrafish , home

    Nov. 21, 2025, 11:00 a.m. | Arndt F. Siekmann, Ph.D., Associate Professor, Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania | Co-Sponsored by the Center for Vascular and Heart Research, Fralin Biomedical Research Institute