The Emergence of Network Activity Patterns - An Early Window to Autism Spectrum Disorder
Natalia De Marco Garcia, Ph.D.
Associate Professor
Department of Neuroscience
The Brain and Mind Research Institute
Weill Cornell Medical College
Pioneers in Biomedical Research Seminar
The Emergence of Network Activity Patterns - An Early Window to Autism Spectrum Disorder
Date: March 14, 2025
Time: 11 a.m. - 12 p.m.
In-person: Room G101 A/B, 4 Riverside Circle, Roanoke, Virginia
Virtual: Watch via Zoom
About this Seminar
During neonatal development, sensory cortices generate spontaneous activity patterns shaped by both sensory experience and intrinsic influences. How these patterns contribute to the assembly of neuronal circuits is not clearly understood. Using in vivo calcium imaging in young mouse pups, Dr. Garcia and her lab show that spatially segregated assemblies of interneuron and pyramidal cells are already active at neonatal stages. In this talk, she will cover recent work from her lab indicating that GABAergic inputs shape network patterns that balance the number of interneurons and pyramidal cells during a critical window of development. In addition, Dr. Garcia will discuss how imaging approaches including longitudinal 2-photon and widefield calcium imaging can be used to study the link between genetic predispositions for neurodevelopmental disorders and their impact on early network dynamics, and functional connectivity.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Neurobiology Research. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.
You May Also Be Interested In...
-
Home Item
Mechanics of Convective Cell Motion , homeJan. 10, 2025, 11:00 a.m. | Michael Murrell, Ph.D., Associate Professor, Department of Biomedical Engineering and Physics, Yale University | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Center – Roanoke
-
Home Item
The Role of Pericytes in Pulmonary Vascular Diseases , homeJan. 17, 2025, 11:00 a.m. | Vinicio de Jesus Perez, M.D., FCCP, FAHA, Assistant Professor, Wall Center Adult PH Clinic Division of Pulmonary and Critical Care Medicine, Stanford School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home Item
Neural Circuits for Social Behaviors , homeJan. 24, 2025, 11:00 a.m. | Marcelo de Oliveira Dietrich, M.D., Ph.D., Associate Professor, Department of Comparative Medicine and Neuroscience, Yale School of Medicine | Co-Sponsored by the Center for Neurobiology Research, Fralin Biomedical Research Institute
-
Home Item
The Role of Exercise-Induced Blood Factor in Partial Reversal of Age-Related Loss of Plasticity in the Brain , homeJan. 31, 2025, 11:00 a.m. | Saul Villeda, Ph.D., Associate Professor, Chair, Department of Biomedical Science, University of California, San Francisco | Co-Sponsored by the Center for Exercise Medicine Research, Fralin Biomedical Research Institute
-
Home Item
Psychosocial Adjustment to Disability and Disability Identity Development , homeFeb. 14, 2025, 11:00 a.m. | Anjali Forber-Pratt, Ph.D., Director of Research, American Association on Health and Disability | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home Item
How Big Med Drives Rising Healthcare Costs and What to Do About It , homeFeb. 20, 2025, 5:30 p.m. (Reception at 5 p.m.) | Vivian Ho, Ph.D., James A. Baker III Institute Chair in Health Economics, Baker Institute for Public Policy, Rice University | Maury Strauss Distinguished Public Lecture