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In Person Seminar: Deciphering the Metabolic Origins of Heart Failure: Towards Novel Therapeutic Targets

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Daniel Kelly, Ph.D.

Daniel Kelly, Ph.D.

Willard and Rhoda Ware Professor 
Penn and CHOP Cardiovascular Institutes
Perelman School of Medicine
University of Pennsylvania
Children's Hospital of Philadelphia

Pioneers in Biomedical Research Seminar: Deciphering the Metabolic Origins of Heart Failure: Towards Novel Therapeutic Targets

Date: March 22, 2024

Time: 11 a.m. - 12 p.m.

About this Seminar

During the development of heart failure, the myocardium undergoes fuel metabolic reprogramming that reduces the capacity for ATP production. This ultimately leads to an “energy starvation” that contributes to the pathogenesis of heart failure. The Kelly Lab has delineated the transcriptional regulatory circuitry that controls mitochondria function and fuel oxidation in the developing heart. In addition, metabolomic and proteomic profiling has identified nodal points for re-balancing the metabolic derangements of the failing heart. Dr. Kelly’s presentation will cover these topics.

Additional Details

This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Vascular and Heart Research. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.

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