In Person Seminar: Adolescent Alcohol, Behavioral Flexibility, and Excitatory/Inhibitory Balance in Control Circuitry
Charlotte Boettiger, Ph.D.
Professor and Director
Behavioral & Integrative Neuroscience Program
Bowles Center for Alcohol Studies
UNC School of Medicine
Pioneers in Biomedical Research Seminar: Adolescent Alcohol, Behavioral Flexibility, and Excitatory:Inhibitory Balance in Control Circuitry
Date: Oct. 20, 2023
Time: 11 a.m. - 12 p.m.
About this Seminar
Impaired behavioral flexibility is frequently observed in both animal models of adolescent alcohol exposure and in adults with a history of alcohol and other substance use disorders. Here Dr. Boettiger will show evidence that in adult humans, self-reported binge alcohol exposure during adolescence is associated with two markers of a shift in excitatory:inhibitory (E:I) balance in a key node of executive control, the dorsolateral prefrontal cortex. The first measure is derived from resting-state EEG recording – the slope of the EEG power spectral slope, with a shallower slope linked to adolescent binge alcohol exposure. The second measure is derived from single voxel magnetic resonance spectroscopy measures of GABA and glutamate/glutamine (Glx). These E:I balance measures are in turn associated with laboratory based task measurements of behavioral flexibility, such that shifts towards excitation in the dorsolateral prefrontal cortex are associated with reduced behavioral flexibility.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Health Behaviors Research and the Addiction Recovery Research Center. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.
You May Also Be Interested In...
-
Home Item
Mechanics of Convective Cell Motion , homeJan. 10, 2025, 11:00 a.m. | Michael Murrell, Ph.D., Associate Professor, Department of Biomedical Engineering and Physics, Yale University | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Center – Roanoke
-
Home Item
The Role of Pericytes in Pulmonary Vascular Diseases , homeJan. 17, 2025, 11:00 a.m. | Vinicio de Jesus Perez, M.D., FCCP, FAHA, Assistant Professor, Wall Center Adult PH Clinic Division of Pulmonary and Critical Care Medicine, Stanford School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home Item
Neural Circuits for Social Behaviors , homeJan. 24, 2025, 11:00 a.m. | Marcelo de Oliveira Dietrich, M.D., Ph.D., Associate Professor, Department of Comparative Medicine and Neuroscience, Yale School of Medicine | Co-Sponsored by the Center for Neurobiology Research, Fralin Biomedical Research Institute
-
Home Item
The Role of Exercise-Induced Blood Factor in Partial Reversal of Age-Related Loss of Plasticity in the Brain , homeJan. 31, 2025, 11:00 a.m. | Saul Villeda, Ph.D., Associate Professor, Chair, Department of Biomedical Science, University of California, San Francisco | Co-Sponsored by the Center for Exercise Medicine Research, Fralin Biomedical Research Institute
-
Home Item
Psychosocial Adjustment to Disability and Disability Identity Development , homeFeb. 14, 2025, 11:00 a.m. | Anjali Forber-Pratt, Ph.D., Director of Research, American Association on Health and Disability | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home Item
How Big Med Drives Rising Healthcare Costs and What to Do About It , homeFeb. 20, 2025, 5:30 p.m. (Reception at 5 p.m.) | Vivian Ho, Ph.D., James A. Baker III Institute Chair in Health Economics, Baker Institute for Public Policy, Rice University | Maury Strauss Distinguished Public Lecture