From Variant Functionality to Resistance in Cancer

About this Seminar

Dr. Hayes seeks to understand the rules and mechanisms governing signal transduction plasticity. Using high-throughput genetic screening approaches, Dr. Hayes's lab has developed systematic strategies to assess variant functionality and resistance to targeted therapies. From their studies, Dr. Hayes's team has identified functionality for previously uncharacterized patient observed EGFR variants. Many of these uncharacterized variants were enriched in the EGFR dimerization domains and were partially dependent on MAPK signaling. The lab has also extended these findings to other HER family members. Together, using high-throughput genetic screening can reveal important insights into mechanisms driving signal transduction plasticity.

Additional Details

This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Cancer Research Center — D.C. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.

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