From Variant Functionality to Resistance in Cancer
Tiki Hayes, Ph.D.
Assistant Professor
Department of Molecular and Medical Pharmacology
UCLA David Geffen School of Medicine
Pioneers in Biomedical Research Seminar
From Variant Functionality to Resistance in Cancer
Date: Sept. 27, 2024
Time: 11 a.m. - 12 p.m.
Archived video
About this Seminar
Dr. Hayes seeks to understand the rules and mechanisms governing signal transduction plasticity. Using high-throughput genetic screening approaches, Dr. Hayes's lab has developed systematic strategies to assess variant functionality and resistance to targeted therapies. From their studies, Dr. Hayes's team has identified functionality for previously uncharacterized patient observed EGFR variants. Many of these uncharacterized variants were enriched in the EGFR dimerization domains and were partially dependent on MAPK signaling. The lab has also extended these findings to other HER family members. Together, using high-throughput genetic screening can reveal important insights into mechanisms driving signal transduction plasticity.
Additional Details
This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Cancer Research Center — D.C. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.
You May Also Be Interested In...
-
Home Item
Social Learning in Borderline Personality Disorder , homeApril 4, 2025, 11:00 a.m. | Sarah Fineberg, M.D., Ph.D., Assistant Professor, Department of Psychiatry, Yale School of Medicine | Co-Sponsored by the Fralin Biomedical Research Institute Center for Human Neuroscience Research
-
Home Item
Bringing Precision Medicine to Psychiatry , homeApril 10, 2025, 5:30 p.m. (Reception at 5 p.m.) | Jordan Smoller, M.D., Sc.D., MGH Trustees Endowed Chair in Psychiatric Neuroscience; Professor of Psychiatry, Harvard Medical School; Professor of Epidemiology, T.H. Chan Harvard School of Public Health; Director, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital | Maury Strauss Distinguished Public Lecture
-
Home Item
Extracellular Vesicles in the Pathogenesis, Diagnosis and Treatment of the Heart , homeApril 11, 2025, 11:00 a.m. | Susmita Sahoo, Ph.D., Associate Professor, Department of Medicine and Cardiology, Icahn School of Medicine at Mount Sinai | Co-Sponsored by the Fralin Biomedical Research Institute Center for Vascular and Heart Research
-
Home Item
A Human-Centric View of Cerebellar Development , homeApril 18, 2025, 11:00 a.m. | Kathleen Millen, Ph.D., Professor, Department of Pediatrics/Genetics, Associate Director and Principal Investigator, Seattle Children's Hospital Research Institute, The University of Washington School of Medicine | Co-Sponsored by the Center for Neurobiology Research, Fralin Biomedical Research Institute
-
Home Item
Molecular and Neurobiological Studies in Rett Syndrome and Other MECP2 Disorders , homeMay 1, 2025, 5:30 p.m. (Reception at 5 p.m.) | Huda Zoghbi, M.D., Professor, Pediatrics, Molecular and Human Genetics, Neuroscience, and Neurology; Director, Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine; Member, National Academy of Medicine | Maury Strauss Distinguished Public Lecture
-
Home Item
A Novel Bispecific Antibody to Target the Brain Tumor Microenvironment , homeMay 2, 2025, 11:00 a.m. | Khuson Yun, Ph.D., Associate Professor, Department of Neurology, Houston Methodist Chair, Neurodegenerative Disease Research, Houston Methodist Research Institute, Weill Cornell Medical College | Co-Sponsored by the Fralin Biomedical Research Institute Cancer Research Center – Roanoke