Pathways and Regulation of Cardiac Nav1.5 Channel Trafficking in Adult Myocytes

About this Seminar

Voltage-gated Nav1.5 channels need to traffic to the lateral surface and intercalated discs of cardiomyocytes to fulfill their function in action potential propagation within and between cardiomyocytes. Dr. Tseng studies the pathways by which Nav1.5 channels traffic to their destinations, and key regulatory mechanisms involving 14-3-3 and scaffolding proteins. The lab uses adenovirus-mediated expression of Nav1.5 constructs tagged with fluorescent proteins and extracellularly exposed epitope in adult ventricular myocytes, in order to track their movements and quantify their cell surface distribution in a relevant cellular context.

Additional Details

This is a free event hosted by the Fralin Biomedical Research Institute and co-sponsored by the institute's Center for Vascular and Heart Research. The Pioneers in Biomedical Research Seminar Series, which runs annually from September to May, has featured leading biomedical researchers from throughout the country since the program began in 2012. The lectures are also open to all members of the Virginia Tech community including graduate students, undergraduates, faculty, and staff, as well as the public.

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